Figure 1

The PVSG/WHO versus the Rotterdam European clinical, molecular and pathological diagnostic criteria for the classification of myeloproliferative disorders and myeloproliferative neoplasms (MPD/MPN): From Dameshek to Georgii, Vainchenker and Michiels 1950-2018

Jan Jacques Michiels* and Hendrik De Raeve

Published: 17 April, 2019 | Volume 2 - Issue 1 | Pages: 027-050

ijbmr-aid1004-g001

Figure 1:

Left. Conceptual change of myeloproliferative disorders (MPD) into myeloproliferative neoplasms: From Dameshek 1950 to Vainchenker 2005 and Michiels 2008. According to Dameshek in 1950 polycythemia vera (PV) is a trilinear MPD due to one hypothetical stimulus has been confirmed by Vainchenker in 2005 to be caused by the JAK2V617F mutation as the cause of trilinear MPNs essential thrombocythemia (ET), PV and secondary myelofibrosis (Michiels 2006). The speculation of Dameshek in 1951 on the MPDs chronic myeloid leykemia (CML), ET, PV and agnogenic myeloid metaplasia (AMM) has been changed into Ph-postive ET and CML vs Ph-negative ET, PV and AMM by the discovery of t(9:22)(q34:q11) in Ph positive CML by Rowley and the BCR/ABL fusion gene and protein, a constitutively activated tyrokinase activity as the cause of Ph-positive CML and ET in the 1980s by Heisterkamp, Groffen & Grosveld Erasmus University Rotterdam in collaboration with Abels, Hagemeyer & Michiels from the Hematology Department Academic Hospital, Dijkzigt, Rotterdam, Netherlands.

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