Published: 17 April, 2019 | Volume 2 - Issue 1 | Pages: 027-050
Figure 1:
Left. Conceptual change of myeloproliferative disorders (MPD) into myeloproliferative neoplasms: From Dameshek 1950 to Vainchenker 2005 and Michiels 2008. According to Dameshek in 1950 polycythemia vera (PV) is a trilinear MPD due to one hypothetical stimulus has been confirmed by Vainchenker in 2005 to be caused by the JAK2V617F mutation as the cause of trilinear MPNs essential thrombocythemia (ET), PV and secondary myelofibrosis (Michiels 2006). The speculation of Dameshek in 1951 on the MPDs chronic myeloid leykemia (CML), ET, PV and agnogenic myeloid metaplasia (AMM) has been changed into Ph-postive ET and CML vs Ph-negative ET, PV and AMM by the discovery of t(9:22)(q34:q11) in Ph positive CML by Rowley and the BCR/ABL fusion gene and protein, a constitutively activated tyrokinase activity as the cause of Ph-positive CML and ET in the 1980s by Heisterkamp, Groffen & Grosveld Erasmus University Rotterdam in collaboration with Abels, Hagemeyer & Michiels from the Hematology Department Academic Hospital, Dijkzigt, Rotterdam, Netherlands.
Read Full Article HTML DOI: 10.29328/journal.ijbmr.1001004 Cite this Article Read Full Article PDF
HSPI: We're glad you're here. Please click "create a new Query" if you are a new visitor to our website and need further information from us.
If you are already a member of our network and need to keep track of any developments regarding a question you have already submitted, click "take me to my Query."