Figure 5

Primary myelofibrosis is not primary anymore since the discovery of MPL515 and CALR mutations as driver causes of mono-linear megakaryocytic and dual megakaryocytic granulocytic myeloproliferation and secondary myelofibrosis

Jan Jacques Michiels* and Hendrik De Raeve

Published: 15 April, 2019 | Volume 2 - Issue 1 | Pages: 018-026

ijbmr-aid1003-g005

Figure 5:

Bone marrow biopsy showing some increase of cellularity (60%) due to increase of primary megakaryocytic and granulocytic myeloproliferation (PMGM) with loose and dense clusters of immature large to giant megakaryocytes with hyperchromatic cloudy (bulbous) nuclei in CALR thrombocythemia (platelets 1296x10/L) and splenomegaly (spleen size 16 cm on echogram) complicated by acquired von Willebrand syndrome in the study o Michiels 2017.

Read Full Article HTML DOI: 10.29328/journal.ijbmr.1001003 Cite this Article Read Full Article PDF

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