Figure 2

Novel European Asiatic Clinical, Laboratory, Molecular and Pathobiological (2015-2020 CLMP) criteria for JAK2V617F trilinear polycythemia vera (PV), JAK2exon12 PV and JAK2V617F, CALR and MPL515 thrombocythemias: From Dameshek to Constantinescu-Vainchenker, Kralovics and Michiels

Jan Jacques Michiels*, King H Lam, Fibo Ten Kate, Dong-Wook Kim, Myungshin Kim, Vasily Shuvaev, Francisca Valster, Vincent Potters, Wilfried Schroyens, Mihaela Andreescu, Adrian Trifa, Achille Pich and Hendrik De Raeve

Published: 03 April, 2020 | Volume 3 - Issue 1 | Pages: 001-020

ijbmr-aid1011-g002

Figure 2:

The heterozygous JAK2V617F mutated acquired thrombocythemia and germline TPO and JAK2V671I or JAK2Q534R mutated hereditary thrombocythemia as well as acquired MPL515 and congenital hereditary MPL505 mutated thrombocythemia (ET) are driven by indirect cytokine activation heterozygous JAK2V617F→STAT5, germline JAK2 or TPO→TpoR = MPL. Direct binding of TPO to the D3D4 domain of TpoRor direct cytokine activation (MPL515 and MPL505) cytokine receptor activation induce an ET phenotype of MPN without features of PV (EEC negative) Michiels, et al. 2014 [27]. CALR mutants Type 1 and 2, but not wild type CALR, did induce STAT5 activation via TpoR (MPL) and GCSFR, but not via EpoR. The STAT5 activation via GSCFR was much weak erthan via TpoR (MPL). The extracelllar domain of TpoR (MPL), but not of EpoR, was indispensible for CALR mutant induced activity and the D1D2 distal part of the extracelluar TpoR domain and its associated N-glycosylation sites but not the TPO binding site in the D3D4 domain Araki, et al. Vainchenker and Kralovics 2017) [65].

Read Full Article HTML DOI: 10.29328/journal.ijbmr.1001011 Cite this Article Read Full Article PDF

More Images

Similar Articles

Recently Viewed

  • The Accuracy of pHH3 in Meningioma Grading: A Single Institution Study
    Mansouri Nada1, Yaiche Rahma*, Takout Khouloud, Gargouri Faten, Tlili Karima, Rachdi Mohamed Amine, Ammar Hichem, Yedeas Dahmani, Radhouane Khaled, Chkili Ridha, Msakni Issam and Laabidi Besma Mansouri Nada1, Yaiche Rahma*, Takout Khouloud, Gargouri Faten, Tlili Karima, Rachdi Mohamed Amine, Ammar Hichem, Yedeas Dahmani, Radhouane Khaled, Chkili Ridha, Msakni Issam, Laabidi Besma. The Accuracy of pHH3 in Meningioma Grading: A Single Institution Study. Arch Pathol Clin Res. 2024: doi: 10.29328/journal.apcr.1001041; 8: 006-011
  • Assessment of Perceptions of Nursing Undergraduates towards Mental Health Practices
    Alya Algamdii* Alya Algamdii*. Assessment of Perceptions of Nursing Undergraduates towards Mental Health Practices. Clin J Nurs Care Pract. 2025: doi: 10.29328/journal.cjncp.1001059; 9: 007-011
  • Multipurpose Antioxidants based on Food Industry Waste: Production and Properties Evaluation
    Toshkhodjaev* Toshkhodjaev*. Multipurpose Antioxidants based on Food Industry Waste: Production and Properties Evaluation. Arch Food Nutr Sci. 2025: doi: 10.29328/journal.afns.1001062; 9: 001-003
  • Relationship between Fertility Diet Score Index Items and Ovulation in Women with Polycystic Ovary Syndrome: A Narrative Review
    Hadis Alimoradi, Faezeh Mashhadi, Ava Hemmat, Mohsen Nematy, Maryam Khosravi, Maryam Emadzadeh, Nayere Khadem Ghaebi and Fatemeh Roudi* Hadis Alimoradi,Faezeh Mashhadi,Ava Hemmat,Mohsen Nematy,Maryam Khosravi,Maryam Emadzadeh,Nayere Khadem Ghaebi,Fatemeh Roudi*. Relationship between Fertility Diet Score Index Items and Ovulation in Women with Polycystic Ovary Syndrome: A Narrative Review. Arch Food Nutr Sci. 2024: doi: 10.29328/journal.afns.1001061; 8: 041-048
  • Evaluation of the LumiraDx SARS-CoV-2 antigen assay for large-scale population testing in Senegal
    Moustapha Mbow*, Ibrahima Diallo, Mamadou Diouf, Marouba Cissé#, Moctar Gningue#, Aminata Mboup, Nafissatou Leye, Gora Lo, Yacine Amet Dia, Abdou Padane, Djibril Wade, Josephine Khady Badiane, Oumar Diop, Aminata Dia, Ambroise Ahouidi, Doudou George Massar Niang, Babacar Mbengue, Maguette Dème Sylla Niang, Papa Alassane Diaw, Tandakha Ndiaye Dieye, Badara Cisé, El Hadj Mamadou Mbaye, Alioune Dieye and Souleymane Mboup Moustapha Mbow*,Ibrahima Diallo,Mamadou Diouf,Marouba Cissé#,Moctar Gningue#,Aminata Mboup,Nafissatou Leye,Gora Lo,Yacine Amet Dia,Abdou Padane,Djibril Wade,Josephine Khady Badiane,Oumar Diop,Aminata Dia,Ambroise Ahouidi,Doudou George Massar Niang,Babacar Mbengue,Maguette Dème Sylla Niang,Papa Alassane Diaw,Tandakha Ndiaye Dieye,Badara Cisé,El Hadj Mamadou Mbaye,Alioune Dieye,Souleymane Mboup. Evaluation of the LumiraDx SARS-CoV-2 antigen assay for large-scale population testing in Senegal. Int J Clin Virol. 2022: doi: 10.29328/journal.ijcv.1001041; 6: 001-006

Read More

Most Viewed

Read More

Help ?