Figure 3

Novel European Asiatic Clinical, Laboratory, Molecular and Pathobiological (2015-2020 CLMP) criteria for JAK2V617F trilinear polycythemia vera (PV), JAK2exon12 PV and JAK2V617F, CALR and MPL515 thrombocythemias: From Dameshek to Constantinescu-Vainchenker, Kralovics and Michiels

Jan Jacques Michiels*, King H Lam, Fibo Ten Kate, Dong-Wook Kim, Myungshin Kim, Vasily Shuvaev, Francisca Valster, Vincent Potters, Wilfried Schroyens, Mihaela Andreescu, Adrian Trifa, Achille Pich and Hendrik De Raeve

Published: 03 April, 2020 | Volume 3 - Issue 1 | Pages: 001-020

ijbmr-aid1011-g003

Figure 3:

According to Constantinescu-Vainchenker low V617F constitutional kinase activity in heterozygous mutated JAK2V617F mutated patients is enough to produce the ET phenotype via the MPL signalling pathway and that higher V617F constitutional kinase activity in JAK2V617F mutated, heterozygous/homozygous or homozygous mutated patients is needed to produce the sequential stages of prodromal, classical and advanced (masked) PV phenotypes via activation of both the EPO and pathways of hematopietic progenitors cells (Table 1). The JAK2V617F dosage hypothesis has been confirmed at the bone marrow haematopoietic stem cell level by the demonstration that endogenous erythroid colonies (EEC) from ET patients are mainly heterozygous for the JAK2V617F mutation, whereas all PV patients are either hetero/homozygous or mainly homozygous for the JAK2V617F mutation (Figure 8).

Read Full Article HTML DOI: 10.29328/journal.ijbmr.1001011 Cite this Article Read Full Article PDF

More Images

Similar Articles

Recently Viewed

  • Management and Therapeutic Strategies for Spinal Muscular Atrophy
    Sheena P Kochumon and Cherupally Krishnan Krishnan Nair* Sheena P Kochumon, Cherupally Krishnan Krishnan Nair*. Management and Therapeutic Strategies for Spinal Muscular Atrophy. J Genet Med Gene Ther. 2024: doi: 10.29328/journal.jgmgt.1001009; 7: 001-007
  • A Critical Review on Some Recent Developments in Comparison of Biological Sequences
    DK Bhattacharya* DK Bhattacharya*. A Critical Review on Some Recent Developments in Comparison of Biological Sequences. J Genet Med Gene Ther. 2024: doi: 10.29328/journal.jgmgt.1001010; 7: 008-014
  • Germline BRCA1 Mutation inSquamous Cell Carcinoma of Oesophagus: Driver versus Passenger Mutation
    Amrit Kaur Kaler*, Shraddha Manoj Upadhyay, Nandini Shyamali Bora, Ankita Nikam, Kavya P, Nivetha Athikeri, Dattatray B Solanki, Imran Shaikh and Rajesh Mistry Amrit Kaur Kaler*, Shraddha Manoj Upadhyay, Nandini Shyamali Bora, Ankita Nikam, Kavya P, Nivetha Athikeri, Dattatray B Solanki, Imran Shaikh, Rajesh Mistry. Germline BRCA1 Mutation inSquamous Cell Carcinoma of Oesophagus: Driver versus Passenger Mutation. J Genet Med Gene Ther. 2024: doi: 10.29328/journal.jgmgt.1001011; 7: 015-019
  • A Review on Heavy Metals in Ecosystems, Their Sources, Roles, and Impact on Plant Life
    Humaira Aslam, Ali Umar, Misbah Ullah Khan*, Shehla Honey, Aman Ullah, Muhammad Ahsan Ashraf, Ghulam Ayesha, Nazia Nusrat, M Jamil, Shahid Khan and Adeel Abid Humaira Aslam, Ali Umar, Misbah Ullah Khan*, Shehla Honey, Aman Ullah, Muhammad Ahsan Ashraf, Ghulam Ayesha, Nazia Nusrat, M Jamil, Shahid Khan, Adeel Abid. A Review on Heavy Metals in Ecosystems, Their Sources, Roles, and Impact on Plant Life. J Genet Med Gene Ther. 2024: doi: 10.29328/journal.jgmgt.1001012; 7: 020-034
  • Individual Treatment Trial of PIGV-Associated Mabry Syndrome with D-Mannose in a Young Child
    Marta Agnes Somorai*, Annabelle Arlt, Peter Krawitz, Jochen Baumkötter and Volker Mall Marta Agnes Somorai*, Annabelle Arlt, Peter Krawitz, Jochen Baumkötter, Volker Mall. Individual Treatment Trial of PIGV-Associated Mabry Syndrome with D-Mannose in a Young Child. J Genet Med Gene Ther. 2023: doi: 10.29328/journal.jgmgt.1001008; 6: 001-004

Read More

Most Viewed

Read More

Help ?