Figure 2

European Clinical Laboratory, Molecular and Pathological (ECMP) criteria for prefibrotic JAK2V617F-Thrombocythemia and Polycythemia Vera versus MPL515- and CALR-Thrombocythemia and Myelofibrosis: From Dameshek to Michiels 1950-2018

Jan Jacques Michiels*, Zwi Berneman, Wilfried Schroyens, Fibo W J ten Kate, King Lam and Hendrik De Raeve

Published: 01 March, 2019 | Volume 2 - Issue 1 | Pages: 001-017


Figure 2:

Spectrum of ET and PV bone marrow features in 155 bone marrow biopsies with clustered enlarged “PV” megakaryocytes of PV patients from the PVSG 01 study ranging from an ET bone marrow picture (A left and middle B): arrows indicate the same area of clustered pleiomorphic megakaryocytes) to a classical PV bone marrow picture (A right) with trilinear eryhtro/megakaryo/granulocytic (EMG) hyperplasia. Source Ellis, et al. PVSG 1986 [11]. Courtesy of Wasserman ASH 1995. Wasserman LR, Berk PD, Berlin NI. Polycythemia Vera and the myeloproliferative disorders. 1995, WB Saunders ISBN 0-7216-4213-6. An ET picture was observed in 10 PV, an ET/PV bone marrow picture with increased cellularity (60-80%) was detected in 45 PV, and a hypercellular (80-100%) PV picture was recorded in 90 evaluable bone marrow biopsies of 155 PV patients, who had a documented increased red cell mass in the PVSG 01 study [11].

Read Full Article HTML DOI: 10.29328/journal.ijbmr.1001002 Cite this Article Read Full Article PDF

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